New GPRA DNA Test*

Generalised Progressive Retinal Atrophy (GPRA) – PRA5

*New DNA Test Now Available*

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20% Discount is available from the AHT up to 1st Sep 2019 by applying the code AHTGS2019 at checkout

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PRA is a blinding disease for which there is no treatment, so developing a DNA test enables breeders and owners to test for this disease and eventually eradicate it from the breed. During a perios of 2 years starting in 2017, the AHT have used a whole genome sequencing approach (reading the entire DNA from an individual) to investigate GPRA in the Giant Schnauzer. Data from PRA-affected cases has been compared against older clear Giant Schnauzers to identify the casual mutation for PRA in these dogs.



GPRA NECAP1 – Novel Gene Found
Thanks to Rebekkah Hitti and her team at the Animal Health Trust NECAP1 has been established as a Novel Candidate Gene for GPRA found in the Giant Schnauzer, and this DNA test is now currently available.

The AHT estimate that approximately 1 in 4715 giant schnauzers will be homozygous for this mutation, and 1 in 35 dogs will be carriers. The sample set included a mixture of pepper/salt, and black Giant Schnauzers and they identified carriers in both colour types. They also found this in additional breeds of German origin, and believe this is an ancestral mutation.

Anyone that took part in the research will be contacted by the AHT and offered their dogs results for the DNA test.

Many thanks to everyone who took part in the research by donating DNA from eye tested Giants.

The full research article can be found on the link below:

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